The global market for DNA read, write and edit applications should grow from $17.0 billion in 2019 to $43.1 billion by 2024 with a compound annual growth rate (CAGR) of 20.5% during the period of 2019-2024.
Report Scope:
The scope of the report includes DNA read, write and edit technologies, applications, industries, initiatives, patents and companies. The markets for read, write and edit products and services are given for 2017, 2018, 2019 (estimated) and 2024 (forecast).
This report reviews the main read, write and edit technologies and explains why genetic variation is important in clinical testing and disease. It then discusses significant large-scale research initiatives that impact read, write and edit applications. Of particular interest is a discussion of population-scale sequencing projects throughout the world, and their likely impact. The main market driving forces for read, write and edit products and services are listed and discussed.
The report quantifies each of the main market segments. The read (sequencing) market is quantified by delivered format, including sequencing workflow products (sample preparation kits and reagents, sequencing instruments and consumables, and informatics) and sequencing services (clinical diagnostics and sequencing services to applied market customers).
The sequencing workflow products market is quantified by type, that is, DNA isolation and extraction; target enrichment; library preparation; and informatics/ecosystems. The sequencing instruments and consumables market is given by platform (Sanger, NGS and 3GS).
The sequencing services market is analyzed by end user application (applied, clinical, and R&D). Within sequencing services, the applied market is analyzed by end-user application (agriculture, biopharma, consumer, microbiology, population-scale genomics, synthetic biology and other).
Also within sequencing services, the clinical market is analyzed and quantified by disease category (cardiovascular, clinical microbiology and infectious diseases, Mendelian disorders, metabolic/immune disorders, neurology, oncology, reproductive health and transplant medicine).
The DNA write (synthesis) market is quantified by product type (oligonucleotides, synthetic biology parts, genes and RNA therapeutics). The oligonucleotide market is analyzed by application (gene editing, sequencing, PCR, FISH, microarray, gene synthesis and other). The gene market is quantified by gene type (standardized, value-added). Finally, the RNA therapeutics market is quantified by platform (RNA interference, antisense oligos, micro RNA modulation and mRNA) and by disease category (cancer, hematology, musculoskeletal, neurology and rare diseases).
The DNA edit (gene editing) market is quantified by application (agriculture, biopharma, diagnostics and therapeutics); editing platform (CRISPR, meganuclease, TALEN, ZFN). The gene editing agriculture market is analyzed by product type (crop/seeds, livestock). The gene editing biotechnology market is analyzed by product type (kits and reagents, cell line engineering, animal models and services). The gene editing therapeutics market is analyzed by disease category (eye and rare diseases).
Specific geographic markets discussed include North America, Europe, Asia-Pacific, and the rest of the world (ROW).
Industry sectors analyzed include next-generation sequencing; long read sequencing; DNA synthesis; RNA therapies; and gene editing.
More than 320 companies in the read, write and edit industry are profiled in this report.
BCC Research also provides a summary of more than 180 of the main industry acquisitions and strategic alliances that took place from January 2018 through June 2019, including key alliance trends.
Report Includes:
- 28 data tables and 77 additional tables
- An overview of the global market for DNA read, write and edit technologies, applications, and industries
- Analyses of global market trends, with market data from 2017, 2018, estimates for 2019, and projections of compound annual growth rates (CAGRs) through 2024
- Discussion on sequencing technologies, market applications, industry structure, and important clinical sequencing initiatives
- Information pertaining to several significant large-scale research initiatives that are contributing to sequencing services, write synthesis and gene editing technologies’ market development
- A look at the innovations in pharmaceutical and biotechnology companies and research & development programs in stem cell-based therapies and gene therapies
- Coverage of significant patents and their allotments in each category, as well as major industry acquisitions and strategic alliances data
- Company profiles of over 320 major global players within the industry, including 3Billion Inc., 23Andme Inc., Bayer AG, Becton, Dickinson and Co. (BD), Bio-Rad Laboratories, Pacific Biosciences, Qiagen NV, Roche Holding AG and Thermo Fisher Scientific Inc.
Summary:
DNA (and RNA) read, write and editing includes the primary methods in which nucleic acids are analyzed (sequencing), created (synthesis) and modified (gene editing). It is becoming increasingly important in the life sciences industry to be expert in all aspects of nucleic acids in order to exploit significant opportunities within this industry. The end users for these technologies include any industry that works with biological systems, and even some that don’t (e.g., DNA data storage).
The DNA read, write and edit industry is at the beginning stages of its growth story; penetration of the key markets is still at an early stage. For example, the cumulative number of human genomes sequenced reached REDACTED as of January 2019 (less than REDACTED of the global human population); we estimate that population-scale projects alone will increase that figure to more than REDACTED genomes sequenced during the next five years. The percentage of non-human species sequenced as of January 2019 was less than REDACTED of all species. These data indicate that there is significant future upside for sequencing across research, metagenomics, agriculture, synthetic biology and clinical applications,
among others.
The situation is similar for DNA writing and editing technologies, with clinical therapeutic applications in particular providing an enormous total available future market that is yet to be significantly penetrated. Major successes in this industry include the adoption of next-generation sequencing (NGS) for noninvasive prenatal testing; enabling the roles of synthetic DNA oligonucleotides and genes in the rise of the synthetic biology industry; and rapid adoption of CRISPR gene editing by research institutions and biopharma industries.
There is increasing interplay among the three DNA technology platforms, giving rise to innovative corporate strategies. For example, Arbor Biotechnologies employs sequencing, gene synthesis and artificial intelligence to perform high-throughput discovery of biomolecules, including new CRISPR proteins.
Table of Contents
Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing the Study
Scope of Report
Methodology
Information Sources
Geographical Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Overview
DNA Read, Write and Edit Technologies and Markets
Large-Scale Initiatives and Consortia
Applications of DNA Read, Write and Edit Technologies
DNA Read, Write and Edit Market Driving Forces
Global DNA Read, Write and Edit Markets
Chapter 4 Technology Background
Introduction to Nucleic Acid Technologies
Genetic Variation and Analysis
Sequencing Technologies
Sanger Sequencing
Next-generation Sequencing
DNA Write (Synthesis) Technologies
PCR-Based Approaches
Solid-Phase-Based Approaches
Microfluidic Technologies
Gene Editing Technologies
CRISPR Enzyme Technologies
Gene Editing Delivery Technologies
Viral Delivery Technologies
Non-Viral Delivery Technologies
Chapter 5 DNA Read, Write and Edit Initiatives
Initiatives
American Gut Consortium
BabySeq
Blood Profiling Atlas
Cancer-ID
Cancer Moon Shots Program
China Precision Medicine Initiative
Clinical Genome Resource
Epigenetics for Females Personalized Cancer Care
France Genomic Medicine Plan
Friends of Cancer Research Project
Gene Therapy Initiative
Human Cell Atlas Consortium
Immunomonitor Consortium
Integration of Imaging and Fluid-based Tumor Monitoring in Cancer Therapy Program
Laboratory for Genomics Research
Liquid Biopsies and Imaging for Improved Cancer Care
Lung Cancer Master Protocol Project
Matchmaker Exchange
Medical Genome Initiative
Metagenomics and Metadesign of Subways and Urban Biomes
Million Veteran Program
Molecular Integration in Neurological Diagnosis
MedSeq
National Microbiome Initiative
Next-generation Single Cell Analysis Program
PreCancer Atlas
Precision Medicine Initiative
Prospective Registry of Multiple Testing
Quality Assurance Initiative Pathology Project
Somatic Cell Genome Editing Program
Telomere-to-Telomere Consortium
Trans Omics for Precision Medicine Initiative
Population Sequencing Programs
Chapter 6 DNA Read, Write and Edit Applications
Applications Overview
Genome Editing Applications
DNA Sequencing Applications
R&D Applications
Applied Applications
DNA Write (Synthesis) Applications
Oligonucleotides
Synthetic Genes
BioBrick (Synbio) Parts
Genome Editing Applications
Cell Engineering
Organism Engineering
Screening and Tools
Chapter 7 DNA Read, Write and Edit Industries
Sequencing Industry
Sequencing Instruments Industry
Long Read Sequencing Industry
DNA Write (Synthesis) Industry
Oligos as Therapeutics
Gene Synthesis Workflow
Gene Synthesis Value Chain
Synthetic Gene Market Segments
Gene Editing Industry
Chapter 8 Acquisitions and Strategic Alliances
Acquisitions
Strategic Alliances
Key Trends
Alliance Summaries
Chapter 9 DNA Read, Write and Edit Markets
Industry Growth-Driving Forces
DNA Read, Write and Edit Technologies
Global DNA Read (Sequencing), Write (Synthesis) and Edit (Gene Edit) Markets
DNA Read (Sequencing) Markets
Clinical Diagnostic Sequencing Market
Cardiology Market
DNA Write (Synthesis) Markets
Gene Editing Market
Market for Gene-edited Crops/Seeds
Gene-edited Livestock Market
Chapter 10 Patents
Circulating Tumor Cell Patents
Exosome Patents
Cell-free DNA Patents
Sequencing-related Patent Issues
Gene Editing-Related Patents
Gene Editing Patents (Sangamo Case Study)
RNA Therapy-related Patents
Chapter 11 Nucleic Acid Read, Write and Edit Company Profiles
3BILLION INC.
10X GENOMICS INC.
23ANDME INC.
ADAPTIVE BIOTECHNOLOGIES INC.
ADMERA HEALTH
ADVERUM BIOTECHNOLOGIES
AGILENT TECHNOLOGIES INC.
AJINOMOTO CO., INC.
ALCEDIAG
ALDEVRON
ALLERGAN PLC
ALLOGENE THERAPEUTICS INC.
ALMAC GROUP LTD.
AMARANTUS BIOSCIENCE HOLDINGS INC.
AMBRY GENETICS
AMFORA INC.
ANCHORDX MEDICAL CO., LTD.
ANNOROAD GENE TECHNOLOGY CO., LTD.
ANSA BIOTECHNOLOGIES INC.
APERIOMICS INC.
ANGES INC.
APEIRON BIOLOGICS AG
ARBOR BIOTECHNOLOGIES INC.
ARCADIA BIOSCIENCES INC.
ARCHER DX
ARCTURUS THERAPEUTICS INC.
ARUP LABORATORIES
ASIA GENOMICS PTE. LTD.
ASTRIDBIO TECHNOLOGIES KFT.
ASURAGEN INC.
ASTRAZENECA PLC
ATG BIOSYNTHETICS GMBH
ATHENA DIAGNOSTICS INC.
ATRECA INC.
ATUM
AVECIA
BASE4 INNOVATION LTD.
BASF AG
BAYER AG
BAYLOR GENETICS
BEAM THERAPEUTICS INC.
BECTON, DICKINSON AND CO.
BENSON HILL BIOSYSTEMS INC.
BERRY GENOMICS CO., LTD.
BGI SHENZHEN
BIOARRAY S.L.
BIO BASIC INC.
BIOCEPT INC.
BIODESIX INC.
BIOGEN INC.
BIOMARX INC.
BIONEER CORP.
BIO-RAD LABORATORIES INC.
BIO S&T INC.
BIO-TECHNE LTD.
BLUEBIRD BIO
BLUE HERON BIOTECH LLC
BLUEPRINT GENETICS
BLUESTAR GENOMICS INC.
B-MOGEN BIOTECHNOLOGIES INC.
BOREAL GENOMICS
BRISTOL-MYERS SQUIBB CO.
BROOKS LIFE SCIENCES
CALYXT INC.
CAMBRIDGE EPIGENETIX LTD.
CANCER GENETICS
CAREDX INC.
CARIS LIFE SCIENCES
CARIBOU BIOSCIENCES INC.
CASEBIA THERAPEUTICS
CASZYME
CATALOG TECHNOLOGIES INC.
CEGAT GMBH
CELGENE CORP.
CELLECTIS SA
CELLMAX LIFE
CELSEE INC.
CENTOGENE AG
CERGENTIS B.V.
CHRONIX BIOMEDICAL
CIBUS INC.
CIRCULOGENE THERANOSTICS
CIRCULOMICS INC.
COFACTOR GENOMICS INC.
COLOR GENOMICS
COOPERSURGICAL, INC.
CORIELL LIFE SCIENCES INC.
COSMOSID
CRISPR THERAPEUTICS AG
CYGNUS BIOSCIENCES CO., LTD.
DANAHER CORP.
DARUI BIOTECHNOLOGY CO., LTD.
DATAR CANCER GENETICS LTD.
DEPIXUS
DESKTOP GENETICS LTD.
DEVYSER AB
DIACARTA INC.
DIAGNOMICS
DIPLOID
DIRECTED GENOMICS LLC
DIRECT GENOMICS CO., LTD.
DNA ELECTRONICS LTD.
DNANEXUS INC.
DNA SCRIPT
DOVETAIL GENOMICS LLC
DOWDUPONT INC.
EDIGENE CORP.
EDIGENE INC.
EDITAS MEDICINE INC.
EGENESIS INC.
ELECTRONIC BIOSCIENCES
ELIGO BIOSCIENCE
ENVISION GENOMICS
EPIC SCIENCES INC.
EPOCH LIFE SCIENCE INC.
ESPERITE NV
ETAGEN PHARMA
EUROFINS SCIENTIFIC
EVONETIX
EXACT SCIENCES CORP.
EXPEDEON AG
EZLIFE BIO INC.
FABRIC GENOMICS
FLUXION BIOSCIENCES INC.
FREENOME INC.
FRY LABORATORIES LLC
FULL GENOMES CORP.
FUSION GENOMICS CORP.
G+FLAS LIFE SCIENCES INC.
GENAPSYS INC.
GENCOVE INC.
GENDX BV
GENE BY GENE LTD.
GENEDX INC.
GENEMED SYNTHESIS INC.
GENERAY BIOTECH CO., LTD.
GENETICS RESEARCH LLC
GENOMATIX SOFTWARE GMBH
GENOME. ONE PTY LTD.
GENOMIC EXPRESSION
GENOMIC HEALTH INC.
GENOME PROFILING LLC
GENOMNIA SRL
GENOMONCOLOGY
GENOSPACE
GENOOX
GENEXOSOME TECHNOLOGIES INC.
GENSCRIPT
GENUS PLC
GIGAGEN INC.
GILEAD SCIENCES INC.
GINKGO BIOWORKS
GOLDEN HELIX
GRAIL INC.
GRANDOMICS BIOSCIENCES CO., LTD.
GUARDANT HEALTH INC.
GUARDIOME
HAPLOX BIOTECHNOLOGY
HELITEC
HELIX OPCO LLC
HELIXWORKS TECHNOLOGIES LTD.
HISTOGENETICS LLC.
HORIZON DISCOVERY GROUP PLC
HTG MOLECULAR DIAGNOSTICS INC.
HOMOLOGY MEDICINES INC.
HUMAN LONGEVITY INC.
ILLUMINA INC.
INEX INNOVATIONS EXCHANGE PTE. LTD.
INIVATA LTD.
INSCRIPTA INC.
INTELLIA THERAPEUTICS INC.
INTERPACE DIAGNOSTICS LLC
INVITAE
INVIVOSCRIBE INC.
IREPERTOIRE INC.
KAILOS GENETICS
KANEKA EUROGENTEC S.A.
KARIUS INC.
KELLBENX INC.
KEW INC.
KINGMED DIAGNOSTICS CENTER CO., LTD.
KWS SAAT SE
LABGENIUS LTD.
LABORATORY CORP. OF AMERICA INC.
LABORATORY FOR MOLECULAR MEDICINE
LC SCIENCES
LGC GROUP
LEUCINE RICH BIO PVT. LTD.
LEXENT BIO INC.
LOCUS BIOSCIENCES
LOGICBIO THERAPEUTICS
LOOP GENOMICS
LUNGLIFE AI, INC.
MACROGEN INC.
MAPMYGENOME
MAYO MEDICAL LABORATORIES
MDXHEALTH INC.
MEDGENOME LABS PVT. LTD.
MENARINI SILICON BIOSYSTEMS SPA
MERCK KGAA
MICROSOFT CORP.
MOGENE LLC
MOLECULAR ASSEMBLIES INC.
MOLECULAR HEALTH GMBH
MOLECULARMD CORP.
MOLECULAR LOOP BIOSOLUTIONS LLC
MYRIAD GENETICS, INC.
N-OF-ONE INC.
NANOSTRING TECHNOLOGIES INC.
NATERA INC.
NAVERIS INC.
NEOGENOMICS LABORATORIES
NEW ENGLAND BIOLABS
NEWGENE LTD.
NEW ONCOLOGY GMBH
NGENEBIO CO., LTD.
NIPD GENETICS
NOVARTIS PHARMA AG
NOVOGENE CO., LTD.
NUCELIS LLC
NUCLERA NUCLEICS LTD.
NUGEN TECHNOLOGIES INC.
NUMEDII
NUPROBE INC.
NX PRENATAL INC.
OCUNEXUS THERAPEUTICS INC.
OMEGA BIO-TEK INC.
OMNISEQ LLC
ONCOCYTE CORP.
ONCODNA S.A.
ONEOME INC.
ONTERA
OTHRAM INC.
OXFORD BIOMEDICA PLC
OXFORD GENETICS LTD.
OXFORD NANOPORE TECHNOLOGIES LTD.
PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
PAIRWISE PLANTS INC.
PANGAEA ONCOLOGY
PARADIGM DIAGNOSTICS INC.
PARSEQ LAB CO., LTD.
PATHWAY GENOMICS CORP.
PERKINELMER INC.
PERSONAL GENOME DIAGNOSTICS INC.
PERSONALIS INC.
PFIZER INC.
PHIO PHARMACEUTICALS CORP.
PIERIANDX
POPULATION GENETICS TECHNOLOGIES LTD.
PORTABLE GENOMICS LLC
POSEIDA THERAPEUTICS INC.
POSITIVE BIOSCIENCE
PRECIPIO INC.
PRECISION BIOSCIENCES INC.
PREDICINE INC.
PRENETICS
PREVENTIONGENETICS INC.
PROMEGA CORP.
Q-STATE BIOSCIENCES
QIAGEN NV
QUANTAPORE INC.
QUANTUM BIOSYSTEMS INC.
QUANTUMDX
QUEST DIAGNOSTICS INC.
RARECYTE INC.
REAL-TIME GENOMICS INC.
RECOMBINETICS, INC.
RESOLUTION BIOSCIENCE INC.
ROCHE HOLDING AG
SANGAMO THERAPEUTICS INC.
SAREPTA THERAPEUTICS INC.
SCREENCELL
SEEKIN
SEQUENCING.COM
SEVEN BRIDGES GENOMICS INC.
SGI-DNA INC.
SHINEGENE MOLECULAR BIO-TECHNOLOGIES INC.
SIGMA ALDRICH CORP.
SHERLOCK BIOSCIENCES
SINGLERA GENOMICS INC.
SISTEMAS GENÓMICOS SL
SOFTGENETICS LLC
SOPHIA GENETICS
SPERA MEDICAL
STA PHARMACEUTICAL CO., LTD.
STRAND LIFE SCIENCES PVT. LTD.
STRATOS GENOMICS INC.
SUPRATECH MICROPATH LABORATORY & RESEARCH INSTITUTE PVT. LTD.
SYNBIO TECHNOLOGIES INC.
SYAPSE
SYNGENTA AG
SYNPROMICS LTD.
SYNTHEGO CORP.
SYNTHETIC GENOMICS INC.
TAKARA BIO
TEMPUS
THERANOSIS LIFE SCIENCES PVT. LTD.
THERMO FISHER SCIENTIFIC INC.
THRIVE EARLY DETECTION CORP.
TOOLGEN
TRACE GENOMICS INC.
TRANSLATE BIO
TROPIC BIOSCIENCES UK LTD.
TWIST BIOSCIENCE
TWINSTRAND BIOSCIENCES
UBIQUITY GENOMICS INC.
VELA DIAGNOSTICS
VEROGEN INC.
VERITAS GENETICS
VIR BIOTECHNOLOGY INC.
VORTEX BIOSCIENCES
XING TECHNOLOGIES LLC
YIELD10 BIOSCIENCES INC.
YIKON GENOMICS CO., LTD.
YOURGENE HEALTH PLC
ZHEJIANG DIAN DIAGNOSTICS CO., LTD.
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