The global sequencing market should grow from $10.7 billion in 2018 to $24.4 billion by 2023, with a compound annual growth rate (CAGR) of 18.0% for the period of 2018-2023.
The scope of the report includes sequencing technologies, applications, industries, initiatives, patents and companies. The markets for sequencing products and services are given for the years 2017, 2018, and 2023.
This report reviews the main sequencing technologies and explains why genetic variation is important in clinical testing. It then discusses some of the significant research initiatives that impact sequencing applications. Of particular interest is a discussion of population-scale sequencing projects throughout the world, and their likely impact on the sequencing industry. The main market driving forces for sequencing products and services are listed and discussed.
The report quantifies the sequencing markets by delivered format, including sequencing workflow products (sample preparation kits and reagents, sequencing instruments and consumables, and informatics) and sequencing services (clinical diagnostics and sequencing services to applied market customers).
The sample preparation kits and reagents market is quantified by type, that is, DNA isolation and extraction; target enrichment; and library preparation. The sequencing instruments and consumables market given by platform (Sanger, NGS and 3GS) and by product type (instruments, consumables).
The sequencing services market is analyzed by end user application (applied, clinical, research and development) and by genome type (human, non-human). Within sequencing services, the applied market is analyzed by end user application (agriculture, biopharma, consumer, microbiology, population-scale genomics, synthetic biology, and other).
Also within sequencing services, the clinical market is analyzed and quantified on a number of levels, including by disease category (cardiovascular, clinical microbiology and infectious diseases, Mendelian disorders, metabolic/immune disorders, neurology, oncology, reproductive health, and transplant medicine); by sequenced region (single gene, targeted region/multi-gene, exome, whole genome, and metagenome); by assay type (screening/early detection, diagnosis, therapy guidance, monitoring).
Within the diagnostics market, the oncology, reproductive health and transplant medicine market segments are analyzed as follows. The oncology market segment is analyzed by assay type; by sequenced region; and by indication (bladder, brain, breast, colorectal, cancer unknown primary, gastrointestinal stromal tumor, kidney, leukemia/lymphoma, lung, melanoma, pan-cancer, prostate, thyroid, and other cancer). The reproductive health market segment is analyzed by assay type; sequenced region; and application (carrier screening, in-vitro fertilization, newborn screening and non-invasive prenatal screening). The transplant market segment is analyzed by assay type; sequenced region; and organ type (lung, heart, liver, and kidney).
Specific geographic markets are discussed, including North America, Europe, Asia-Pacific, and the rest of the world.
Industry sectors analyzed include Sequencing instruments; long-read sequencing; target enrichment; gene editing; informatics; blockchain; liquid biopsy; reproductive health diagnostics; consumer genomics; agriculture; and DNA data storage.
More than 200 companies in the sequencing industry are profiled in this report.
BCC Research provides a summary of the more than 200 of the main industry acquisitions and strategic alliances from January 2017 through March 2019, including key alliance trends.
- 27 data tables and 79 additional tables
- An overview of global market for DNA sequencing and discussion of applications in research, applied and clinical markets
- Analyses of global market trends, with data from 2017, 2018, and projections of compound annual growth rates (CAGRs) through 2023
- Description of sequencing markets by workflow, including sample preparation products; sequencing instruments and consumables; informatics; and sequencing services
- Coverage of Sanger and next-generation technologies in detail
- Detailed description of key sequencing research & development programs such as American Gut Consortium, BabySeq and Blood Profiling Atlas
- A look at the current trends and recent developments in the market
- Company profiles of the major players of the market, including 23Andme Inc., Mayo Medical Laboratories, Novogene Co. Ltd., Qiagen NV, Roche Holding AG, Thermo Fisher Scientific Inc. and Zhejiang Dian Diagnostics Co. Ltd.
The DNA sequencing industry has achieved significant growth from its beginnings to become a vital sector in life sciences. Illumina, the sequencing leader, has twenty years of sequential revenue growth and the company’s 2018 revenues of approximately $REDACTED billion represented a REDACTED% increase over 2017 revenue. Even with impressive past growth, the industry is still in the early stages of its growth story.
The cumulative number of human genomes sequenced reached REDACTED million as of January 2019 (less than REDACTED% of the global human population); we estimate that population-scale projects alone will increase that figure to more than REDACTED million genomes sequenced by 2023.
Non-human species sequenced as ofJanuary 2019 was less than REDACTED% of all species. These data indicate that there is significant future upside for sequencing across research, metagenomics, agriculture, synthetic biology and clinical applications, among others.
Sequencing plays a central role in several life science megatrends, including precision medicine, synthetic biology, population and consumer genomics; liquid biopsy; tissue-agnostic drugs; blockchain technologies, gene editing, and shift toward consumerism. These major trends favor increasing sequencing adoption and growth in the future.
As an example, in clinical diagnostics there is a move toward a more consumer-focused model. This will drive the demand for genomics technologies because consumers will want to better understand the part that genes and genetic variations have in their future health outcomes.
Key developments in the three key sequencing sectors—research, applied, and clinical–add to the sequencing growth story.
Major developments in the research space include growth of large-scale sequencing initiatives and support for sequencing by the major governmental funding agencies.
Major developments in the applied space include proliferation of population-scale sequencing projects around the globe; use of sequencing by biopharma for selection of patients for clinical trials of precision medicines; and growth in synthetic biology and agriculture applications.
Population-scale sequencing projects, as an example, have multiple positive effects on the sequencing market. These projects give insights into genetic variation within and across populations; advance knowledge of how genetic variation contributes to disease diagnosis, risk prediction and treatment; and facilitate development of new sequencing tools and analysis methods. We have identified more than twenty projects covering the sequencing of the genomes of REDACTED million people by 2023.
Major developments in the clinical space include the launch and rapid growth of NIPT, companion diagnostics for drug development and for tissue-agnostic drugs; and a growing installed base of sequencing instruments for genetic testing. Important clinical sequencing applications include reproductive health; oncology; rare and undiagnosed diseases; and transplant medicine.
Table of Contents
Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Overview
Sequencing Growth Driving Forces
Chapter 4 Technology Background
Importance of DNA
Genetic Variation and Analysis
History of Sequencing
Next Generation Sequencing
Mapping to a Reference Sequence
Clinical Sequencing Adoption Challenges
Chapter 5 Sequencing Initiatives
American Gut Consortium
Blood Profiling Atlas
Cancer Moon Shots Program
China Precision Medicine Initiative
France Genomic Medicine Plan
Friends of Cancer Research Project
Human Cell Atlas Consortium
Integration of Imaging and Fluid-based Tumor Monitoring in Cancer Therapy Program
Liquid Biopsies and Imaging for Improved Cancer Care
Metagenomics and Metadesign of Subways and Urban Biomes (MetaSub)
Million Veteran Program
National Microbiome Initiative
Next Generation Single Cell Analysis Program
Precision Medicine Initiative
Population Sequencing Programs
Chapter 6 Research and Applied Applications
Research and Development Applications
Direct to Consumer
Chapter 7 Clinical Applications
Mendelian Disorders Applications
Reproductive Health Applications
Microbiology and Infectious Disease Applications
Complex Disorders Applications
Transplant Diagnostics Applications
Chapter 8 Sequencing Industry
Sequencing Instruments Industry
Long Read Sequencing Industry
Target Enrichment and Amplification Industry
Gene Editing Industry
Sequencing Informatics Industry
Sequencing Data-Based Blockchain Industry
Liquid Biopsy Assay Industry
Reproductive Health Diagnostics Industry
Non-invasive Prenatal Testing Industry
Fetal Cell NIPT Industry
Consumer Genomics Industry
DNA Data Storage Industry
Chapter 9 Acquisitions and Strategic Alliances
Chapter 10 Sequencing Markets
Growth Driving Forces
Sequencing Instruments and Consumables Market
Sample Prep Kits and Reagents Market
Sequencing Services Market
Consumer Genomics Market
Population Genomics Market
Synthetic Biology Market
Clinical Diagnostic Sequencing Market
Clinical Microbiology and Infectious Disease Market
Mendelian Disorders Market
Metabolic/Immune Disorders Market
Reproductive Health Market
Single Gene Market
Exome Sequencing Market
Whole Genome Sequencing Market
Screening/Early Detection Market
Therapy Guidance Market
Cancer Clinical Diagnostics Sequencing Market
Lung Cancer Market
Breast Cancer Market
Colorectal Cancer Market
Oncology Screening/Early Detection Market
Oncology Diagnosis Market
Oncology Therapy Guidance Market
Oncology Monitoring Market
Role of Novel Biomarkers for Oncology Therapy Guidance and Monitoring
Reproductive Health Markets
Newborn Screening Market
Carrier Screening Market
Chapter 11 Patent Review/ New Developments
Circulating Tumor Cell Patents
Cell-free DNA Patents
Sequencing-Related Patent Disputes
Chapter 12 Company Profiles
10X GENOMICS, INC.
ADAPTIVE BIOTECHNOLOGIES INC.
AGILENT TECHNOLOGIES INC.
ALMAC GROUP LTD.
AMARANTUS BIOSCIENCE HOLDINGS INC.
ASTRIDBIO TECHNOLOGIES KFT.
ATHENA DIAGNOSTICS INC.
BASE4 INNOVATION LTD.
BECTON, DICKINSON AND CO.
BELLWETHER BIO INC.
BERRY GENOMICS CO. LTD.
BIO-RAD LABORATORIES INC.
BLUESTAR GENOMICS INC.
CAMBRIDGE EPIGENETIX LTD.
CARIS LIFE SCIENCES
COFACTOR GENOMICS INC.
COOPER SURGICAL INC.
CORIELL LIFE SCIENCES INC.
CS GENETICS LTD.
CYGNUS BIOSCIENCES CO. LTD.
CYNVENIO BIOSYSTEMS INC.
DATAR CANCER GENETICS LTD.
DARUI BIOTECHNOLOGY CO. LTD.
DIRECTED GENOMICS LLC
DIRECT GENOMICS CO. LTD.
DNA ELECTRONICS LTD.
DOVETAIL GENOMICS LLC
EPIC SCIENCES INC.
EXACT SCIENCES CORP.
EZLIFE BIO INC.
FLUXION BIOSCIENCES INC.
FRY LABORATORIES LLC
FULL GENOMES CORPORATION
FUSION GENOMICS CORP.
GENE BY GENE LTD.
GENETICS RESEARCH LLC
GENOMATIX SOFTWARE GMBH
GENOME.ONE PTY LTD
GENOMIC HEALTH INC.
GENOME PROFILING LLC
GENXOSOME TECHNOLOGIES INC.
GRANDOMICS BIOSCIENCES CO. LTD.
GUARDANT HEALTH INC.
HELIX OPCO LLC
HTG MOLECULAR DIAGNOSTICS INC.
HUMAN LONGEVITY INC.
INEX INNOVATIONS EXCHANGE PTE. LTD.
INTERPACE DIAGNOSTICS LLC.
KINGMED DIAGNOSTICS CENTER CO. LTD.
LABORATORY CORP. OF AMERICA INC.
LABORATORY FOR MOLECULAR MEDICINE
LEUCINE RICH BIO PVT. LTD.
LEXENT BIO INC.
MAYO MEDICAL LABORATORIES
MEDGENOME LABS PVT. LTD.
MENARINI SILICON BIOSYSTEMS SPA
MOLECULAR HEALTH GMBH
MOLECULAR LOOP BIOSOLUTIONS LLC
MYRIAD GENETICS INC.
NANOSTRING TECHNOLOGIES INC.
NEW ENGLAND BIOLABS
NEW ONCOLOGY GMBH
NGENEBIO CO. LTD.
NOVOGENE CO. LTD.
NUGEN TECHNOLOGIES INC.
NX PRENATAL INC.
OXFORD NANOPORE TECHNOLOGIES LTD.
PACIFIC BIOSCIENCES OF CALIFORNIA INC.
PARADIGM DIAGNOSTICS INC.
PARSEQ LAB CO. LTD.
PATHWAY GENOMICS CORP.
PERSONAL GENOME DIAGNOSTICS INC.
POPULATION GENETICS TECHNOLOGIES LTD.
PORTABLE GENOMICS LLC
QUANTUM BIOSYSTEMS INC.
QUEST DIAGNOSTICS INC.
REAL TIME GENOMICS INC.
RESOLUTION BIOSCIENCE INC.
ROCHE HOLDING AG
SEVEN BRIDGES GENOMICS INC.
SINGLERA GENOMICS INC.
SISTEMAS GENÓMICOS SL
STRAND LIFE SCIENCES PVT. LTD.
STRATOS GENOMICS INC.
SUPRATECH MICROPATH LABORATORY & RESEARCH INSTITUTE PVT. LTD.
TAKARA BIO INC.
THERMO FISHER SCIENTIFIC INC.
TRACE GENOMICS INC.
TWO PORE GUYS INC.
UBIQUITY GENOMICS INC.
XING TECHNOLOGIES LLC
YIKON GENOMICS CO. LTD.
YOURGENE HEALTH PLC
ZHEJIANG DIAN DIAGNOSTICS CO. LTD.
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