The global market for protein expression should grow from $1.8 billion in 2017 to $3.1 billion by 2022 at a compound annual growth rate (CAGR) of 11.3% from 2017 through 2022.
Report Scope:
This research report presents an in-depth analysis of the global market for protein expression by system type, products and services, applications, end users and regional markets. The report includes key protein expression systems that are incorporated in several therapeutic treatment methods. It discusses the role of supply chain members from manufacturers to researchers. The report provides an in-depth analysis of key companies operating in the global market for protein expression. A patent analysis focuses on describing technological trends across periods of time and regions, such as the U.S., Europe and Japan.
The protein expression market is mainly segmented into the following system types: prokaryotic expression systems, mammalian cell expression systems, insect cell expression systems, yeast expression systems, cell-free expression systems and algal-based expression systems. This market is further segmented based on products and services into reagents, expression vectors, competent cells, instruments and services. The market study details end users and applications, and ongoing activity in the research and development area. The market is segmented by region into North America, Europe, Asia-Pacific and the rest of the world (ROW). Companies profiled in this report include Thermo Fisher Scientific Inc., Merck KGaA, Promega Corp., Agilent Technologies, GenScript, Takara Holdings Inc., Bio-Rad Laboratories Inc., Qiagen N.V., Lonza and others.
Report Includes:
- 45 data tables 34 additional tables
- An overview and in-depth analysis of the global markets for protein expression technologies
- Analyses of global market trends with data from 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2022
- Discussion on perfusion approaches and supporting practices such as continuous bio manufacturing, and digital and model-based controls
- Identification of key market dynamics and the factors impacting the global market for protein expression and its sub-segments
- Regional dynamics of the global protein expression market and analysis of trends and opportunities in major regions covering North America, Europe, Asia-Pacific and the rest of the world (ROW)
- A relevant patent analysis focuses on describing technological trends across periods of time and regions, such as the U.S., Europe and Japan
- Detailed analysis of the cloning technologies, production of recombinant proteins and problems associated with protein production
- Assessment of major stakeholders, product portfolios and recent developments and the competitive landscape among market leaders
- Company profiles of leading global payers, including Agilent Technologies, Bio-Rad Laboratories Inc., Merck KGaA, Promega Corp., GenScript, Thermo Fisher Scientific Inc., and Qiagen N.V.
Summary
Protein expression is a technique where three processes—translation, transcription and posttranslational modification—play a vital role in the various applications, including biologics production, therapeutic protein production and research application. There are three types of recombinant protein expression methods. These include in vivo protein expression, in vitro protein expression and chemical protein synthesis. It is critical to have access to a variety of expression tools to ensure the successful expression of the required target protein.
Based on the functional need in the host cell, proteins can be modified, regulated and synthesized in different living organisms. These proteins need a specific intracellular environment to achieve the required secondary and tertiary structures. Some proteins also require post-translational modifications or insertion into a cellular membrane to attain the proper functioning of the protein. In addition, the production of some proteins could also be toxic for the well-being of the host. Hence, there is no single solution for the successful production of different types of recombinant proteins.
In this report, the protein expression market is studied through different perspectives. The market is analyzed through the products and their applications in the treatment of several chronic diseases. The protein expression market is categorized into six types based on system type: prokaryotic expression system, mammalian cell expression system, insect cell expression system, yeast cell expression system, cell-free expression system and algal-based expression system. The prokaryotic expression system registered a revenue of REDACTED in 2016 and is poised to increase at a compound annual growth rate (CAGR) of REDACTED throughout the forecast period. Its revenue is projected to reach REDACTED by 2022.
The global market for protein expression based on products and services is segmented into five categories: reagents, expression vectors, competent cells, instruments and services. The reagents segment has dominated the global market for protein expression and is anticipated to do so during the forecast period. This segment accounted for a revenue of REDACTED in 2016, registering a CAGR of REDACTED; this revenue is expected to reach nearly REDACTED by 2022.
By geography, the global market for protein expression is divided into North America, Europe, Asia-Pacific and the Rest of World (ROW). North America held the largest market share in 2016 and accounted for REDACTED, growing at the CAGR of REDACTED during the analysis period. It is anticipated that market will reach nearly REDACTED by 2022. Europe held the second-largest market share of the protein expression market globally. It accounted for REDACTED in 2016 and is expected to reach REDACTED by 2022 at a CAGR of REDACTED. The Asia-Pacific market accounted for REDACTED in 2016 and is expected to reach REDACTED by 2022 at a CAGR of REDACTED. ROW includes Brazil, Saudi Arabia, and South Africa. The ROW protein expression market accounted for REDACTED in 2016 and is expected to reach REDACTED by 2022 at a CAGR of REDACTED.
Table of Contents
Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources and Methodology
Intended Audience
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
Market Definition
Protein Expression Market Overview
Choice of Cell Type
Choice of Plasmid
Choice of Cell Expression System
Introduction to Protein Expression Systems
Protein Synthesis Machinery
What is Protein Expression?
How Proteins Are Made
Transcription and Translation
Perfusion Approaches and Supporting Practices (e.g., Continuous Bio Manufacturing and Digital and Model-based Controls)
Post-translational Modification
Cloning Technologies
Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
Production of Recombinant Proteins
Recombinant Protein Expression Methods
Why Produce Proteins Recombinantly?
Comparison of Expression Systems
Post-translational Processing
Problems Associated with the Production of Protein
Loss of Expression
Ongoing Clinical Trials for Protein Expression
Market Dynamics
Drivers
Restraints
Opportunities
Chapter 4 Global Market for Protein Expression Systems by Type
Introduction
Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
Characteristics of Various Recombinant Protein Expression Systems
Prokaryotic Expression Systems
Promoters
E. coli Systems
Other Prokaryotic Expression Systems
Mammalian Cell Expression Systems
Mammalian Expression Vectors Characteristics
Chinese Hamster Ovary (CHO) Systems
Other Mammalian Cell Systems
Insect Cell Expression Systems
Baculovirus Systems
Yeast Expression Systems
K. Lactis Systems
Saccharomyces Systems
Pichia Systems
Cell-Free Expression Systems
Algal-Based Expression Systems
Chapter 5 Global Market for Protein Expression by Products and Services
Overview
Reagents
Acids and Bases
Acrylamides
Buffers/Buffer Salts
Cell Lysis
Detergents
General Reagents
Labware
Protease Inhibitors
Solvents
Expression Vectors
Commonly Used Expression Hosts
Competent Cells
Instruments
Bioreactor Systems
Services
Protein Expression Services
Benefits
Specific Services Provided by Organizations
Chapter 6 Global Market for Protein Expression by Application
Introduction
Medicine
Research
Biotechnology
Therapeutic
Traditional Recombinant and Newer Cell Therapies including Stem Cell
Industrial
Research
Chapter 7 Global Market for Protein Expression by End User
Overview
Pharmaceutical and Biotechnology Companies
Academic Research Institutes
Contract Research Organizations
Others
Chapter 8 Global Market for Protein Expression by Region
North America
U.S.
Canada
Mexico
Europe
U.K.
Germany
France
Rest of Europe
Asia-Pacific
China
Japan
Australia
India
South Korea
Taiwan
Rest of Asia
ROW
Brazil
Saudi Arabia
South Africa
Others
Chapter 9 Government Regulations
General Manufacturing Guidelines
Control of Starting/Source Materials
Expression Vector and Host Cell
Cell Bank System
Cell Culture Medium/Other Materials
Control of the Manufacturing Process
Cell Culture
Purification
Control of Drug Substance and Drug Product
Characterization
Routine Control
Chapter 10 Patent Review
Patent Analysis
Patents and Patent Applications Filed by Institutions
Chapter 11 Competitive Landscape
Acquisition
Thermo Fisher Scientific Acquired Affymetrix
Product Launches
Chapter 12 Company Profiles
ABNOVA (TAIWAN) CORP.
ACCELAGEN INC.
AGILENT TECHNOLOGIES INC.
BIOMATIK
BIO-RAD LABORATORIES INC.
DOMAINEX LTD.
ENZO LIFE SCIENCES INC.
EXON BIOSYSTEMS
GENSCRIPT
LONZA GROUP AG
LUCIGEN CORP.
MERCK KGAA
NEW ENGLAND BIOLABS INC.
NOVOPROTEIN SCIENTIFIC INC.
ORIGENE TECHNOLOGIES INC.
OXFORD EXPRESSION TECHNOLOGIES LTD.
PROMEGA CORP.
PROTEOGENIX INC.
QIAGEN INC.
R&D SYSTEMS INC.
SINO BIOLOGICAL INC.
SYNGENE
SYNTHETIC GENOMICS INC.
TAKARA HOLDINGS, INC.
THERMO FISHER SCIENTIFIC INC.
Chapter 13 Appendix: Uses of Protein Expressions Systems
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